South Africa begins own production of groundbreaking HIV-prevention drug to make it affordable within the continent

Publicerad denFörfattareHarry Markham

South Africa will soon begin production of the groundbreaking HIV-prevention drug, long-acting cabotegravir (CAB-LA), finally making the life-saving treatment affordable within the African continent. The treatment, which must be injected every two months, almost entirely eliminates the risk of becoming infected by HIV through sex. This development is expected to help millions of people at risk within Africa.  
Following a collaborative agreement between the developers of CAB-LA, ViiV Healthcare, and the United Nations-backed Medicine Patent Pool (MPP), an HIV-preventative will be produced in South Africa for the first time. This has great implications for Africa as a whole, with an affordable solution to a problem that has long been a source of pain for the continent.
A patent-free, highly effective HIV-prevention drug
A branded version does exist, and in the USA just one injection costs $3,500. But thanks to this new agreement which was announced in March 2023, a generic version of the drug can finally be produced. A generic drug is a pharmaceutical drug that contains the same chemical substance as a drug that was originally protected by chemical patents. This is important as it drastically cuts the cost involved for governments looking to obtain the treatment for their populations. While there are already free of cost HIV-prevention drugs available across much of Africa, they must be taken daily and are not as effective as the long-lasting cabotegravir injection, which must only be taken every two months. The drug almost entirely eliminates the risk of becoming infected by HIV through sex.
It is rare for medicine to be produced within Africa, despite certain drugs such as HIV-preventatives being in higher demand there than anywhere else. In fact, only 38 countries across the world have any drug manufacturers, and even less than that actually develop new drugs. The new availability of this highly effective drug is expected to help millions of Africans who are currently at risk of HIV infection.
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Cooperation on producing generic drugs saves lives
The company which will produce the drug, an Indian group called Cipla, received permission to do so back in March through an agreement between its developers and the United Nations-supported MPP. The MPP state that:
“Our mission is to increase access to, and facilitate the development of, life-saving medicines for LMICs. We do this through an innovative approach to voluntary licensing and patent pooling.”
To achieve this goal, they work hand in hand with civil society, international organisations, industry, patient groups and governments. Between 2012 and 2021, through partnerships with 18 patent holders and 56 generic manufacturers, they provided 26.91 billion doses of treatment, saving at least 18,000 lives.
The work of groups such as the MPP is essential to ensuring that low-income nations can give essential and life-saving care to their populations. Often, people in need are left to suffer and potentially die because they do not have access to specialist medicines. The developers of the medicines themselves are usually guilty of financial gatekeeping, driving for profit as opposed to producing medicine for the common good.
Securing HIV-prevention drug is a big victory, but the fight continues
The gatekeeping of essential and lifesaving drugs by pharmaceutical companies has long been a problem. This problem really came to attention during the COVID pandemic, when rich nations were able to buy up billions of doses of the vaccine – more than they needed – while low-income nations were left to suffer.
Allowing Cipla to produce the vital drug in South Africa is a big first step, but there is still a lot more that could be achieved through further cooperation with drug producers. Firstly, allowing more companies to produce the same drug will improve availability and help to negate future shortages, as long as the companies which receive access to the knowledge are ready to produce in the quantities required. In addition to this, increased competition means lower prices. The US based Food and Drug Administration showed in one report that products with six or more generic producers were on average 95% cheaper than when only a single branded option was available.
Regardless of the imperfect situation, the ability to produce a generic version of CAB-LA in South Africa will save countless lives and is a victory in the ongoing struggle to make lifesaving drugs available to all in need. Läs mer…

South Africa begins own production of groundbreaking HIV-prevention drug to make it affordable within the continent

Publicerad denFörfattareRss .

South Africa will soon begin production of the groundbreaking HIV-prevention drug, long-acting cabotegravir (CAB-LA), finally making the life-saving treatment affordable within the African continent. The treatment, which must be injected every two months, almost entirely eliminates the risk of becoming infected by HIV through sex. This development is expected to help millions of people at […]

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Swamps as a climate saver: Ireland stores tons of CO₂ through 33,000 hectares of new peatlands

Publicerad denFörfattareNoah Duker

Ireland is reforesting its swamps and bogs in a bid to fight climate change. Although marshlands cover only three percent of the earth, they store 25 percent of the world’s CO2. So far, around 8100 hectares on the “green island” have been flooded with water. The “watering” is intended to create optimum conditions for new peat land. Experts believe that the “renaturation” project will store enormous amounts of climate-damaging greenhouse gases.
Peatlands are considered to be the ecosystem with the greatest storage potential for CO₂. When a plant dies, the CO₂ stored in it is released into the water or into the marsh soil as it decays, rather than into the air. Bogs and marshlands are therefore true climate protectors!
Trees store CO₂ and release oxygen This process is called photosynthesis. When trees die and rot, they release the remaining CO₂ into the environment, especially into the air. However, if a tree falls into a swamp, the CO₂ is not released into the air but stored in the water and soil. If the swamp dries up, and thus also the CO₂-containing mixture, peat is formed. Over thousands of years, a well-known raw material is created from it: coal!
Ireland is reforesting swamps and peatlands to fight climate change
Until the industrial revolution, almost one fifth of Ireland was covered with peatlands. From the 1850s until today, people have destroyed large parts of Ireland’s nature – that is, besides marshlands, also countless forests. The partly state-owned company “Bord na Móna” wants to revive nature and make Ireland the green lung of Europe to fight climate change. For this reason, they are filling 33,000 hectares of alluvial land with water over the next few years. They also want to reintroduce native species of plants and animals that have been driven or wiped out over the years. Currently, just under a quarter, or 8125 hectares, has been “reforested.”
How Ireland’s marshlands were destroyed and rebuilt
The reason for the poor condition of Ireland’s peatlands is historical. The tradition of “peat cutting” has been preserved and carried on for generations. The peat, when dried, is a good fuel. For the economy, especially during the industrialization, the peat was in great demand because it could be found everywhere on the island and was therefore very cheap. Peat was also used to heat the houses in Ireland.
Another reason for the large-scale drainage of the Irish peatlands is agriculture. During the Industrial Revolution, Ireland developed not only railroads and cities, but also agriculture on a large scale. For the cultivation of food, large areas of marshland were destroyed.
Even at the beginning of industrialization, the destruction of the marshes was already underway: by the end of the 19th century, Ireland was more industrialized than the whole of Austro-Hungarian Empire or Spain, two countries that were significantly larger in terms of area and population. The partly state-owned Irish company “Bord na Móna” and others now wants to declare war on environmental destruction and make the “emerald isle” live up to its name again.
This work is licensed under the Creative Common License. In case of new republication, please cite NeueZeit.at/Noah Düker as the Source/Author and set a link to the article in English: https://scoop.me/ireland-climate-change-peatlands/
The rights to the content remain with the original publisher. Läs mer…

Swamps as a climate saver: Ireland stores tons of CO₂ through 33,000 hectares of new peatlands

Publicerad denFörfattareRss .

Ireland is reforesting its swamps and bogs in a bid to fight climate change. Although marshlands cover only three percent of the earth, they store 25 percent of the world’s CO2. So far, around 8100 hectares on the “green island” have been flooded with water. The “watering” is intended to create optimum conditions for new […]

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Breakthrough: New gel shown to be effective for brain tumour treatment

Publicerad denFörfattareNoah Duker

A new “miracle” gel shows great promise for brain tumour treatment during lab tests at Johns Hopkins University. The gel is used to treat one of the most aggressive forms of brain tumour, glioblastoma, leaving patients with a diagnosed life expectancy of 12 – 18 months. The new treatment is used post-surgery to fill the spaces left by the removed tumour, hindering it from regrowing!
Professor Cui, an expert on chemical and biomolecular engineering, and his team say that the gel could even be used to treat areas of the brain that surgery might not be able to reach. Other than that, tests on infected mice have shown that the gel removed 100 percent of the aggressive tumour, freeing them from certain death. Furthermore, the gel seemed to create an immune reaction that allowed surviving mice, who were reinfected with glioblastoma, to fend off the tumour on their own using only their immune system. It also showed signs of improving immune memory, leading to a generally strengthened immune system post treatment. 
Despite the breakthrough, the medical procedure is still risky since brain surgery is still required for the gel to work effectively, having to be applied directly to the brain. Using the gel without surgery first led to a survival rate of around 50 percent. 
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For those interested in the science behind the miracle: the gel uses a combination of nano-sized filaments, extracted from the approved drug paclitaxel which then transports the antibody called aCD47. The mixture then expands upon the crevice that the tumour left, leaving the aggressive cancer with no room to regrow, thereby killing it off. 
Brain Tumour Treatment: Glioblastoma – aggressive and everywhere
There are a few reasons why Glioblastoma is so dangerous. The tumour is fast-growing and infects surrounding tissue, which can make surgical removal even harder. Another reason is the brain’s own defence mechanism, known as the blood brain barrier or BBB for short. This barrier normally hinders harmful substances from entering the brain, but also does the same for cancer treating drugs, leading to treatments being less effective.
Glioblastoma’s location in the human brain also doesn’t help with its treatment as it is usually located in the cerebral hemispheres of the brain, which are responsible for critical functions such as movement, sensation, and cognition. This makes surgical intervention more risky, as injuring healthy brain tissue can lead to serious neurological problems.
Science deniers and conspiracy believers are trying to push an anti-science agenda
In the past century, medicine has come a long way. From the times of experimental treatments using drugs like heroin and cocaine to the first effective polio vaccine developed in 1955 by Dr. Jonas Salk, ending the terror of infantile paralysis.
The medical developments of the past few years, however, have been even more marvellous. Science managed to make breakthrough after breakthrough. From healing patients with HIV, a sickness that used to be untreatable and therefore a death sentence, to stopping a global pandemic within two years of the outbreak.
Modern science is leading humanity to longer and healthier lives. But the security and development that scientific research has brought to fruition has come under attack as of recent. Science deniers and conspiracy believers are trying to push an anti-science agenda, smearing scientific fact as wrong or “fake news”, attesting that scientists are either bought by a mysterious elite or some other delusion, just because science does not back their opinion on certain topics. In today’s age of information, having sources and research is key to being informed. Therefore, it is necessary to honour and protect proper scientific research from delusional attacks such as those we saw during the covid pandemic. Because without modern science, life as we know it would be a lot shorter, and a lot less enjoyable, as the case of Glioblastoma makes evermore clear. Läs mer…

Breakthrough: New gel shown to be effective for brain tumour treatment

Publicerad denFörfattareRss .

A new “miracle” gel shows great promise for brain tumour treatment during lab tests at Johns Hopkins University. The gel is used to treat one of the most aggressive forms of brain tumour, glioblastoma, leaving patients with a diagnosed life expectancy of 12 – 18 months. The new treatment is used post-surgery to fill the […]

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Washington State bans AR-15-style semi-automatic rifles

Publicerad denFörfattareHarry Markham

On April 25th, Washington State took decisive action in reducing the risk of gun violence and particularly mass shootings within their borders with the introduction of three new gun control bills. The bills bring into law a ban on some styles of semi-automatic rifles, introduce a ten-day waiting period between the purchase of a firearm and its reception by the buyer, and make lawsuits against gun makers or sellers possible in certain cases. While the signing Governor recognises that the bills “don’t solve all the problems”, the state has taken an important step in reducing the risk of mass gun violence.
Between 2015 and 2021, Washington state suffered 31 mass shootings. While mass shootings are not the most common form of gun violence – greatly outnumbered by single victim homicides – they often act as a catalyst for gun reform due to the attention and shock they garner both locally and across the world. This is the case in Washington, where three new bills have been introduced in an attempt to ensure that the residents of the “Evergreen State” never have to suffer such a tragedy again.
The new bills tackle mass shootings in Washington State
The bills, which were signed by Washington State Governor Jay Inslee on Tuesday the 25th of April, introduce three new restrictions designed to reduce the risk of gun violence.
A ban on certain semi-automatic rifles
One bans the sale of certain AR- and AK- style semi-automatic rifles. The focus on this style of gun is significant for a couple of reasons. Firstly, weapons such as the AR-15 can do great damage to crowds of people in a very short period of time. They are powerful, accurate, fire at a rapid rate, and are generally easy to obtain in the US. For this reason, they have become the weapon of choice for people seeking to carry out a mass shooting, with the weapon having been used in ten of the 17 deadliest mass killings that have taken place since 2012. The ban, while not getting to the root of the problem, means that prospective killers in Washington will likely have to settle for something less deadly.
The bill’s intent section gives the following reasoning for the ban:
“Assault weapons have been used in the deadliest mass shootings in the last decade. An assailant with an assault weapon can hurt and kill twice the number of people than an assailant with a handgun or nonassault rifle.”
Secondly, the AR-15 in particular has become a symbol of the conservative American right. The gun, which is more at home on a battlefield than it is in the streets, fields and forests of the US, has little-to-no practical use for the average American. Despite this – and the fact that the gun is now forever linked to the slaughter of school children and innocent civilians – republican politicians and their supporters alike continue to pose with glee alongside their prized weapon.

Merry Christmas! 🎄ps. Santa, please bring ammo. 🎁 pic.twitter.com/NVawULhCNr
— Thomas Massie (@RepThomasMassie) December 4, 2021

This idolisation of the popular mass murder device is exemplified in the fact that senior republican figures Lauren Boebert and George Santos co-sponsored a bill that would make the AR-15 the “national gun of the USA” in February 2023. For many on the right, it is more a question of having it because they can, not because they need to – whatever the human cost.
A ten-day waiting period for buyers, and the risk of legal repercussions for manufacturers
The new bills don’t just target buyers, they also target manufacturers and sellers. From now on, those in a position to provide firearms must take steps to ensure that weapons are not sold to people known to be dangerous, or people who might be buying the gun to pass it on to someone else. They must also ensure that the weapons are manufactured and marketed responsibly. Should they be found to have failed in any of these measures, it is now possible to sue manufacturers over any future violations or damages.
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The aforementioned ten-day waiting period is designed to provide a buffer period between people in crisis and their possession of a deadly weapon. During this period the buyer must also provide evidence that they have completed the required safety training. The hope is that this short period will reduce the risk of people buying and using a deadly weapon during a time of anger or mental instability.
Washington’s gun control bills only a drop in the ocean
Over the course of 2023 so far, 14,427 people have lost their lives to gun violence in the United States and 11,412 have been injured. While mass shootings are the most widely publicised due to their shocking nature, they only account for a small portion of overall deaths (212 out of 14,427). While banning certain styles of semi-automatic rifle will help prevent devastating mass shootings, the majority of shootings which are carried out with a wide array of guns, will continue. In 2021, over 6,000 murders were confirmed to have been committed using a handgun, compared to 447 by rifle. While there were a further 4,740 cases in which the gun type was not recorded, it is clear that only banning certain styles of semi-automatic rifles is like putting a band-aid on a gunshot wound, with an estimated 1.4 million guns having been sold in the US last month alone.
Inslee, the governor who signed the bills into law, also recognises these bills as a drop in the ocean, stating:
“Just because they don’t solve all the problems does not mean the state of Washington does not take action… Inaction against gun violence is unacceptable.”
Gun reform in the US is a gradual and difficult process
As the world watches on as seemingly weekly news of school, supermarket, church or street shootings filters out of America, gun reform advocates should not hold their breath in hope of an absolute ban. Despite strong support for regulations such as requiring background checks on all gun sales, banning assault weapons, and not selling firearms to those with potentially dangerous mental health issues (88%, 67% and 84% support respectively), there is no great call for a widespread ban on ownership. But tragedy after tragedy, protest after protest, and bill by bill, gun reform activists and supporters hope that they are moving towards a time where widespread gun violence in the US is a thing of the past – and these three bills are certainly a step in that direction. Läs mer…

Washington State bans AR-15-style semi-automatic rifles

Publicerad denFörfattareRss .

On April 25th, Washington State took decisive action in reducing the risk of gun violence and particularly mass shootings within their borders with the introduction of three new gun control bills. The bills bring into law a ban on some styles of semi-automatic rifles, introduce a ten-day waiting period between the purchase of a firearm […]

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EU adopts the World’s first Regulation on Cryptocurrencies

Publicerad denFörfattareRss .

The EU-Parliament passed a law to regulate cryptocurrencies like Bitcoin more strongly. The new regulation will protect consumers from losses, and it will make money laundering and terrorist financing more difficult. In addition, providers are to be held liable in the event of massive losses. With the new law, Europe wants to end the “wild […]

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EU adopts the World’s first Regulation on Cryptocurrencies

Publicerad denFörfattareScoop Editorial

The EU-Parliament passed a law to regulate cryptocurrencies like Bitcoin more strongly. The new regulation will protect consumers from losses, and it will make money laundering and terrorist financing more difficult. In addition, providers are to be held liable in the event of massive losses. With the new law, Europe wants to end the “wild west of the blockchain world”.
On 20 April, the EU-Parliament passed the so-called “Regulation on Markets in Crypto Assets” (MiCA) with a large majority. Until now, it was possible to trade cryptocurrencies largely anonymously. Bitcoin & Co. are therefore popular with money launderers and fraudsters. This is now to come to an end.
Crypto exchanges will be subject to national supervisory authorities
Insider trading and abuse of power are to be made more difficult by the regulation. Service providers and suppliers of crypto-assets must submit to money laundering regulations. In addition, platforms and crypto exchanges will be subject to national supervisory authorities. Those platforms on which cryptocurrencies can be traded must also provide information about the sender and recipient of the transactions.
This is the first law to comprehensively regulate cryptocurrencies such as Bitcoin, Etherum, etc. Evelyn Regner, Vice-President of the EU Parliament, comments on the decision:
“With this law, we are not only creating a model for the regulation of crypto markets, but above all strengthening the protection of consumers and investors and increasing legal certainty for providers.
EU Regulation on Cryptocurrencies makes money laundering and terrorist financing more difficult
At the same time, the regulation ensures that trading with Bitcoin & Co. can be better tracked. Suspicious transactions that are related to money laundering or terrorism, for example, can thus be identified more quickly.
“This is long overdue, because under the guise of innovation, cryptocurrencies are often a convenient way to cover up criminal money flows. A whole 22 billion euros were laundered through crypto assets in 2022. This must now be put to an end,” Regner said.
The regulation is to come into force in stages from 23 June. From July 2024, crypto-assets tied to currencies – so-called stablecoins – will then have to prove larger financial reserves in order to be approved. The complete regulation will then come into force in January 2025 at the latest. The “Wild West of the blockchain world” will thus come to an end, according to European Parliament member Stefan Berger.
Bitcoin mining consumes as much energy as the whole of Austria every year
However, Regner points out that the EU’s regulation on cryptocurrencies is only a first step: “However, not all the work is done with the regulation adopted today, because crypto markets continue to develop rapidly. Therefore, the EU Commission should continue to closely monitor developments in the crypto asset markets and propose further regulation if needed.”
Especially in the area of sustainability, it is imperative to tighten up: “Bitcoin mining alone consumes as much energy annually as the whole of Austria. Therefore, in the future, we will also need minimum standards for sustainability, which have not made it into the regulation for the time being due to considerable resistance from the centre-right.” Läs mer…